Anti-Inflammatory drugs and the heart
The June 19th issue of circulation carries an epidermiological study by the Danish group, reviewing 58,400 patients who had suffered their first heart attack between 1995-2002, and who were taking anti-inflammatory agents for pain relief, both selective Cox2 and NSAID. They found that those who were on normal dose of Cox2 and those who were on high doses of NSAID were at increased risk of a second heart attack and death from the heart attack. The Cox2 reviewed included Vioxx, Celebrex and the NSAID reviewed included ibudrufen and diclofinec. The message is clear, if you have heart disease, especially after an AMI, do not take COX2 or high dose NSAID. If you should need pain relief for whtever reason, it may be wise to take normal dose NSAID with a pump inhibitor to protect against gastropathy.
1 comment:
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